It has been known for some time that the human body has an endocannabinoid system. It is part of the human nervous system and is also called the endogenous cannabinoid system. Central components of this system are two cannabinoid receptors, the CB1 and the CB2 receptor. Cannabinoids, or endocannabinoids, can dock to these receptors and activate them. THC can also dock to these receptors and exert its effect.

The endocannabinoid system helps your body communicate with the brain. Meanwhile, further functions of the system are already known, which have to do with our feelings, the perception of pain and our mood. It is particularly interesting for researchers to understand the possible interactions between the body's own endocannabinoids and the cannabinoids of the hemp plant.

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Where does the endocannabinoid system come from?

How does the endocannabinoid system work?

The endocannabinoid system and cannabis

Where does the endocannabinoid system come from?

In the mid-1960s, THC was discovered as a psychoactive component of the hemp plant. However, cannabis was already known as a medicinal plant by the Egyptians. The hemp plant used to be used for pain relief and mental cleansing. It was only when research became more and more involved with the components of the hemp plant that the endocannabinoid system was discovered in 1992.

Research was conducted into the effects of cannabinoids from the hemp plant and came across the endocannabinoid system, whose receptors interact with the cannabinoids. Researchers found that there were not only cannabinoids from the hemp plant, but also endogenous endocannabinoids. The first endogenous cannabinoid discovered is called anandamide. The term is derived from the Sanskrit word "ananda" for bliss.

The endocannabinoid system is not yet fully understood, and its effects, as well as other cannabinoids, have yet to be discovered.

How does the endocannabinoid system work?

The endocannabinoid system is part of the human nervous system and has receptors to which endogenous and exogenous cannabinoids can dock. Normally, the endocannabinoid system is regulated by the body's own cannabinoids without outside influence. However, cannabinoids from outside can also interact with this system. In particular, the over 100 cannabinoids found in the cannabis plant can influence this system. CBD is one of the most researched cannabinoids to date and is said to have a calming effect via the endocannabinoid system, for example. However, this has not yet been conclusively proven by science.

The body has two central receptors within the endocannabinoid system. They are located throughout the body and have different functions. Mainly, these receptors are said to be responsible for keeping us in balance. The technical term for our biochemical balance is also called homeostasis. In homeostasis, our body tries to keep hormones, enzymes, and endocannabinoids balanced so that we feel balanced.

Basically, endocannabinoids are used to communicate our body with the brain. After a stimulus, they are produced by our body and can then dock to the endocannabinoid receptors. Afterwards, the endocannabinoids are broken down again. The effect of the endocannabinoid system thus unfolds in order to be able to process stimuli.

Research to date has recognized two types of cannabinoid receptors, cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). While the CB1 receptor is commonly found in nerve cells, particularly in the brain and gut, the CB2 receptor is more likely to be found in the immune system and on cells involved in bone formation and breakdown.

The receptors of the endocannabinoid system have different functions. CB1 receptors, for example, are clustered in the region of the brain responsible for our movement and information processing. They are also located in the areas of the brain that are important for our motivation as well as cognitive functions. CB2 receptors are increasingly found in the central nervous system, which is responsible for our immune system and our immune defense.

The activation of the cannabinoid receptors takes place through the endocannabinoids. These endocannabinoids are not stored in the nerve cells like most other neurotransmitters. The endocannabinoid anandamide binds primarily to the CB1 receptor, while the endocannabinoid 2-arachidonylglycerol (2-AG) binds to the CB2 receptor. When these endocannabinoids dock with the receptors, they trigger a reaction in the body. This can affect our mood, memory, concentration, and even our perception of pain. For example, there is an interesting connection between reading a book or jogging and higher endocannabinoid levels. This probably explains why we feel so good afterwards. Jogging and reading can increase our well-being and improve our mood.

The endocannabinoid system and cannabis

The endocannabinoids that are found in the endocannabinoid system are produced by the body itself. However, there are also plant cannabinoids that can interact with this system. These cannabinoids come from the hemp plant. The two most well-known cannabinoids are THC and CBD.

The plant cannabinoids have a similar structure to the body's own endocannabinoids. Therefore, they can also bind to the CB1 and CB2 receptors. Thus, they can also activate the receptors, just like the body's own endocannabinoids.

THC can have psychoactive effects on the body. It mainly binds to the CB1 receptor, which is predominantly found in the brain. The reaction can affect memory and perception or the feeling of hunger. For this reason, THC also falls under the narcotics law.

But CBD as a cannabinoid can also bind to the receptors of the endocannabinoid system. It has no psychoactive effect and is even said to cause THC to be broken down more quickly. CBD has less binding power on the cannabinoid receptors. At the same time, it ensures that other cannabinoids are less able to bind to the receptors of the endocannabinoid system. In exchange, CBD can bind to other receptors in our body, such as the serotonin receptor, or inhibit the enzymes that break down our body's own endocannabinoids. This keeps our endogenous endocannabinoids like anandamide in the body longer. Therefore, research suggests that CBD may support and keep our endocannabinoid system in balance. However, this has not yet been conclusively proven.

Plant cannabinoids from the hemp plant can therefore communicate with our endocannabinoid system and influence our body's own endocannabinoid levels. This is exactly why researchers are becoming more and more interested in the cannabinoids found in the hemp plant and their influence on the endocannabinoid system. We are curious!